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Senior Research Scholar - Metabolomics

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North Carolina State University

Job Description

Posting Number

PG193454EP

Internal Recruitment

No

Working Title

Senior Research Scholar - Metabolomics

Anticipated Hiring Range

$85,000 - $107,573 (commensurate with education and experience)

Work Schedule

8:00 AM - 5:00 PM, Monday-Friday

Job Location

Raleigh, NC

Department

METRIC Mass Spectrometry Platform Technology

About the Department

The overarching goal of the Molecular Education, Technology and Research Innovation Center (METRIC) is to offer clients seamless access to qualitative and quantitative analysis for a diverse range of molecules, supporting research across multiple platform technologies and molecular scales. By coordinating three key platform technologies (Mass Spectrometry, NMR spectroscopy and X-ray crystallography), METRIC provides an integrated, measurement science facility that fosters research and collaboration throughout the greater university community. METRIC provides researchers access to the following services:

  • Mass spectrometry: small molecule identification and structural analysis, targeted and untargeted metabolomics, proteomics, lipidomics, MS imaging.
  • NMR spectroscopy: small molecule and macromolecular solution structures, protein-ligand interactions, protein dynamics.
  • X-ray crystallography: small molecule and macromolecular crystal structure determination.
  • Education, training and outreach: METRIC offers training to new users, enhances graduate and undergraduate education through providing formal instruction, organizing educational materials, short courses and workshops to support users, maintaining protocols for routine sample handling, and hosting regular forums for users to interact and share new methods.

Essential Job Duties

Duties include, but are not limited to:

1. Experimental Consultation and Design:

  • Serve as the point of contact for client inquiries in the area of small molecule analysis by targeted and untargeted metabolomics, including lipidomics.
  • Provide expert advice on experimental design, including selection of sample preparation techniques and analytical methods, to ensure methodological rigor and feasibility.
  • Collaborate with other staff members to develop and optimize metabolomics experimental protocols.
  • Stay abreast of the latest advances in analytical methods and techniques to integrate into research projects.


2. Sample Preparation and Acquisition:

  • Perform liquid, liquid-liquid, or SPE extraction, derivatization, and other pre-analytical steps to ensure sample integrity and suitability for downstream analysis.
  • Operate and maintain LC-MS metabolomics instrumentation (e.g. Thermo TSQ Altis Triple Quadrupole, Exploris 240, Exploris 480, ID-X).
  • Develop and implement standard operating procedures (SOPs) for sample handling and preparation to ensure consistency across studies.

3. Data Analysis and Interpretation:

  • Perform metabolomics studies and report the results (analyte peak area or concentrations) using relevant software such as Skyline, MS-Dial, and Compound Discoverer.
  • Use appropriate statistical and bioinformatics tools to extract meaningful biological insights.
  • Perform pathway analysis using specialized software and databases, as needed.
  • Interpret complex datasets and collaborate with researchers to contextualize findings within the scope of the project.
  • Prepare detailed reports and visualizations of data for internal review, publication in scientific journals, and inclusion in grant applications.

4. Administrative Responsibilities:

  • Maintain accurate and up-to-date laboratory records, including experimental protocols, data logs, and inventory of samples and reagents.
  • Coordinate with the operations manager to ensure adequate supplies; ensure continuity of operations by coordinating maintenance of major instrumentation and associated ancillary equipment.
  • Assist in the training and supervision of staff and students in metabolomics techniques and best practices.
  • Contribute to the preparation of manuscripts, grant applications, and progress reports for funding agencies.
  • Ensure compliance with institutional and regulatory requirements related to biosafety, data management, and ethical standards.

Additional duties as assigned based on institutional needs and priorities.

Other Responsibilities

Other duties as assigned.

Minimum Education and Experience

  • Ph.D. in a relevant field, with at least five years of experience in metabolomics research methods and/or post-degree professional work experience with a demonstrated record of research achievement.

OR
  • Relevant Master’s degree, plus at least 8 years of exceptional relevant professional work experience and a record of research achievements.
OR
  • In rare instances, an individual with comparable professional experience but less than a master’s degree will be considered, on an exception basis. May require terminal degree and licensure.

Other Required Qualifications

  • Significant experience in untargeted and targeted metabolomics, advanced separations, tandem MS, absolute quantification, IROA, credentialing, bioinformatics, and metabolome databases.
  • Demonstrated ability to develop workflows and standard operating procedures (SOPs).
  • Must possess exceptional communication skills, including written and verbal, be highly organized and detail-oriented.
  • Must be able to work independently, use initiative, prioritize tasks, and anticipate potential pressure points in workflows.
  • Ability to develop and maintain productive collaborative work relationships with all clients by listening, understanding and responding to apparent and underlying needs and continually seeking to provide the highest quality service to all.

Preferred Qualifications

  • Prefer experience with lipidomics and/or mass spectrometry-based imaging.
  • Prefer experience with integrating data from multiple-omics based approaches.

Required License(s) or Certification(s)

N/A

Valid NC Driver's License required

No

Commercial Driver's License required

No

Job Open Date

06/11/2024

Anticipated Close Date

Open Until Filled

Special Instructions to Applicants

Please attach resume, cover letter, and contact information for three professional references.
Email inquires should be sent to Joe Barycki, Director, METRIC, at joe_barycki@ncsu.edu

Position Number

00050194

Position Type

EHRA Non-Faculty

Full Time Equivalent (FTE) (1.0 = 40 hours/week)

1.00

Appointment

12 Month Recurring

Mandatory Designation - Adverse Weather

Non Mandatory - Adverse Weather

Mandatory Designation - Emergency Events

Non Mandatory - Emergency Event

Department ID

210204 - METRIC Mass Spectrometry Platform Technology

AA/EEO

NC State University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, national origin, religion, sex, gender identity, age, sexual orientation, genetic information, status as an individual with a disability, or status as a protected veteran. Individuals with disabilities requiring disability-related accommodations in the application and interview process are welcome to contact 919-515-3148 to speak with a representative at the Office of Institutional Equity and Diversity.

If you have general questions about the application process, you may contact Human Resources at (919) 515-2135 or workatncstate@ncsu.edu.

Final candidates are subject to criminal & sex offender background checks. Some vacancies also require credit or motor vehicle checks. Degree(s) must be obtained prior to start date in order to meet qualifications and receive credit.

NC State University participates in E-Verify. Federal law requires all employers to verify the identity and employment eligibility of all persons hired to work in the United States.

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